In Guillain-Barre syndrome, Guillain-Barre syndrome, a rare autoimmune disease. Your immune system — which usually attacks only invading organisms — begins attacking the nerves. In AIDP , the nerves’ protective covering (myelin sheath) is damaged. The damage prevents nerves from transmitting signals to your brain, causing weakness, numbness or paralysis. It occurs when the immune system attacks the nerves controlling muscles in the legs and sometimes the arms and upper body. Weakness results, which can sometimes be severe.
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